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Lycopene-A 5 Alpha Reductase Inhibitor




      The benefits of Lycopene for the prevention of Prostate Cancer has been well established. A new study showed Lycopene to be beneficial for Prostate Enlargement and PSA reduction, and identified 5 alpha reductase type 1 inhibition as the specific mechanism by which it worked. This would have implications for the treatment of hair loss as this is the same mechanism by which Propecia works.

      Research done by Dr. Limpens would clearly suggest that the COMBINATION of Lycopene and Vitamin E succinate , based on their identified mechanisms, would pack a punch not only against prostate enlargement/cancer, but androgenetic alopecia as well.

      Integrating Lycopene and Vitamin E succinate into an existing treatment regime cost next to nothing , and would appear to offer a health promoting alternative to Proscar/Propecia or Avodart, without the risks of sexual dysfunction and gynecomastia,(male breast enlargement).

      Lycopene is also present in the Ultra Natural Prostate Formula, likely contributing to its efficacy as a hair loss treatment.

      "lycopene interfered with local androgen activation by down-regulating 5-alpha-reductase, the key enzyme for the transformation of testosterone to its most active form dehydrotestosterone (DHT). As a consequence, the expression of androgen-regulated target genes was also reduced."

      Vitamin E and lycopene combo tested in humans 01/10/2004 - After confirming that a combination of vitamin E and lycopene has a positive effect on the growth of prostate tumours in mice, scientists in the Netherlands have initiated a trial in men suffering from the disease.

      Researchers led by Dr. Jacqueline Limpens from the Erasmus Medical Center in Rotterdam, said yesterday that the combination slowed the growth of prostate tumours in mice and that a study testing the compounds in cancer patients is now under way.

      She and her team tested low and high doses of synthetic lycopene, the carotenoid found naturally in tomatoes, alone and combined with vitamin E against a placebo in mice injected with human prostate cancer cells.

      "It was the low dose of both lycopene and vitamin E that was the most effective, demonstrating that 'more does not necessarily equal better'," said Limpens.

      She reported that the combination reduced the growth of the tumors by 73 per cent by the forty-second day of the trial.

      "We would certainly recommend that all men regularly eat lycopene and vitamin-E-rich foods including processed tomato products, papayas, pink grapefruit and watermelon, wheat germs, whole grains, mangoes, leafy green vegetables, nuts and olive oils," she added.

      Earlier this year, researchers from DSM were the first to discover - in experiments carried out on a rat model - that lycopene may reduce the risk of prostate cancer by inhibiting the male hormone’s effect on the prostate, and that feeding the rat vitamin E and lycopene in combo caused an enhanced killing rate of tumour cells.

      Their analysis revealed that both nutrients affected gene expression directly in the tumours: lycopene interfered with local androgen activation by down-regulating 5-alpha-reductase, the key enzyme for the transformation of testosterone to its most active form dehydrotestosterone (DHT). As a consequence, the expression of androgen-regulated target genes was also reduced.

      In addition, lycopene decreased the expression of two prostatic cytokines, IGF-I and IL-6, both regarded as risk factors for prostate cancer. Vitamin E reduced androgen signaling without affecting androgen metabolism.

      Prostate problems and Male Pattern hair loss occur at an unusually high rate industrial countries.

      Integrating Lycopene and Vitamin E succinate into an existing treatment regime cost next to nothing , and would appear to offer a health promoting alternative to Proscar/Propecia or Avodart, without the risks of sexual dysfunction and gynecomastia,(male breast enlargement).

      Lycopene is also present in the Ultra Natural Prostate Formula, likely contributing to its efficacy as a hair loss treatment.

Articles of Interest

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