Add this to the list of studies showing a strong association with male pattern hair loss and inflammation. The studies done thus far have conclusively identified a localized inflammation around the hair follicle, known as “perifollicular” inflammation, which is actually more central to hair loss than hormones per se. This particular study goes a step further drawing an association with MPB, abdominal weight gain, and systemic inflammation.
Background: Previous investigations have revealed an association of androgenetic alopecia (AGA), especially in younger subjects with severe early-onset AGA, with ischemic heart disease. Objective: To examine the possible association between early-onset alopecia and low-grade inflammation measured by high-sensitivity C-reactive protein (hs-CRP) that has been recommended for the assessment of the cardiovascular disease (CVD) risk. Methods: The study population consisted of young men (n = 727, aged 25-34 years) participating in a national survey. The grade of alopecia was assessed by a trained nurse using the Norwood/Hamilton Classification Scale. Results: Men with moderate to extensive alopecia (17%) had a higher body mass index and larger waist, upper arm, hip and waist circumference than those with little to no alopecia (p < 0.05), and statistically insignificant differences were seen in the waist-to-hip circumference ratio (WHR), diastolic blood pressure and hs-CRP. With increasing hs-CRP, the mean WHR increased, but only among men with moderate to extensive alopecia (p = 0.043). Conclusion: Our findings show a relation between moderate to extensive alopecia and low-grade inflammation - a predictor of a future CVD - especially combined with central obesity, among men younger than 35 years. Copyright (c) 2007 S. Karger AG, Basel.
This may at least in part explain the overwhelmingly positive feedback we consistently receive regarding the efficacy of our hair loss treatment protocol. There are numerous compounds in our protocol that have established anti-inflammatory effects. Our protocol combines the simultaneous usage of both systemic and topical agents that give health and anti-aging benefits that go well beyond the scope of hair loss treatment, and put the kabosh on systemic and localized inflammation associated with hair loss.
As the above study indicated, Male Pattern hair loss is associated with metabolic syndrome as well as low grade systemic inflammation. The hallmark of metabolic syndrome is excess fat accumulation around the abdomen. Green Tea Extract has been conclusively shown to reduce waist circumference if you use enough of it. Interestingly this effect has been shown to occur in the absence of any co-variables, such as diet and exercise.
There are also significant dietary associations with hair loss, inflammation, metabolic syndrome, or lack thereof. This may also partially explain why Asians in rural areas who eat little to no refined foods, rarely go bald, while those who have lived in the U.S. more than one generation have an epidemiological equivalent rate of hair loss as that of the general population of the U.S. A previous update goes into more detail.
In a past update we mentioned that “Promel”, a compound developed by L’Oreal, would soon hit the market for the treatment of gray hair. The following study showed an interesting effect of oral Tribulus extract, that is its apparent ability to restore hair pigmentation in rats. Tribulus has been used for years in the bodybuilding community to raise testosterone, often between steroid cycles. The human dose equivalent used in the study would be obscenely high, however, a mere fraction of that dose may work for those wishing to experiment. Tribulus is widely available at most Nutrition stores.