Hair loss, Inflammation, and Metabolic Syndrome

    Add this to the list of studies showing a strong association with male pattern hair loss and inflammation. The studies done thus far have conclusively identified a localized inflammation around the hair follicle, known as “perifollicular” inflammation, which is actually more central to hair loss than hormones per se. This particular study goes a step further drawing an association with MPB, abdominal weight gain, and systemic inflammation.

Dermatology, 2007; 214(2):125-9.

Obesity and Low-Grade Inflammation among Young Finnish Men with Early-Onset Alopecia.

Hirsso P, Rajala U, Hiltunen L, Jokelainen J, Keinanen-Kiukaanniemi S, Nayha S.
University of Oulu, Department of Public Health Science and General Practice, Oulu, Finland.

Background: Previous investigations have revealed an association of androgenetic alopecia (AGA), especially in younger subjects with severe early-onset AGA, with ischemic heart disease. Objective: To examine the possible association between early-onset alopecia and low-grade inflammation measured by high-sensitivity C-reactive protein (hs-CRP) that has been recommended for the assessment of the cardiovascular disease (CVD) risk. Methods: The study population consisted of young men (n = 727, aged 25-34 years) participating in a national survey. The grade of alopecia was assessed by a trained nurse using the Norwood/Hamilton Classification Scale. Results: Men with moderate to extensive alopecia (17%) had a higher body mass index and larger waist, upper arm, hip and waist circumference than those with little to no alopecia (p < 0.05), and statistically insignificant differences were seen in the waist-to-hip circumference ratio (WHR), diastolic blood pressure and hs-CRP. With increasing hs-CRP, the mean WHR increased, but only among men with moderate to extensive alopecia (p = 0.043). Conclusion: Our findings show a relation between moderate to extensive alopecia and low-grade inflammation - a predictor of a future CVD - especially combined with central obesity, among men younger than 35 years. Copyright (c) 2007 S. Karger AG, Basel.

This may at least in part explain the overwhelmingly positive feedback we consistently receive regarding the efficacy of our hair loss treatment protocol. There are numerous compounds in our protocol that have established anti-inflammatory effects. Our protocol combines the simultaneous usage of both systemic and topical agents that give health and anti-aging benefits that go well beyond the scope of hair loss treatment, and put the kabosh on systemic and localized inflammation associated with hair loss.

    Some the most potent systemic anti-inflammatory compounds used in our protocol are Green Tea Extract, (a hair loss treatment superstar for many reasons), Grape Seed Extract w/Resveratrol, Root Food, and Natural Estrogen with Pomegranate Extract.
    Topically, our protocol integrates Emu Oil, Ketoconazole (Nizoral and/or Revita Shampoo), Copper peptides, nano, and spin traps (Dr. Proctor’s Advanced Hair Regrowth Formula).

Green Tea Extract-Also Good for the Waistline

As the above study indicated, Male Pattern hair loss is associated with metabolic syndrome as well as low grade systemic inflammation. The hallmark of metabolic syndrome is excess fat accumulation around the abdomen. Green Tea Extract has been conclusively shown to reduce waist circumference if you use enough of it. Interestingly this effect has been shown to occur in the absence of any co-variables, such as diet and exercise.

    This may imply that you could eat, and do exactly what you are doing or not doing now and still lose abdominal fat with Green Tea Extract.
    There are several identified mechanisms by which Green Tea is able to do this. Some of them are: increased thermogenesis and exercise capacity, reduced blood levels of nisulin, and the inhibition of fat digestion and absorption.

There are also significant dietary associations with hair loss, inflammation, metabolic syndrome, or lack thereof. This may also partially explain why Asians in rural areas who eat little to no refined foods, rarely go bald, while those who have lived in the U.S. more than one generation have an epidemiological equivalent rate of hair loss as that of the general population of the U.S. A previous update goes into more detail.

An Herb for Gray hair?

In a past update we mentioned that “Promel”, a compound developed by L’Oreal, would soon hit the market for the treatment of gray hair. The following study showed an interesting effect of oral Tribulus extract, that is its apparent ability to restore hair pigmentation in rats. Tribulus has been used for years in the bodybuilding community to raise testosterone, often between steroid cycles. The human dose equivalent used in the study would be obscenely high, however, a mere fraction of that dose may work for those wishing to experiment. Tribulus is widely available at most Nutrition stores.

    Raising testosterone and getting rid of gray hair at the same time is an intriguing possibility to say the least.
2006 Dec; 26(12):1777-9. [Effect of Tribulus terrestris extract on melanocyte-stimulating hormone expression in mouse hair follicles] [Article in Chinese]

* Yang L, * Lu JW, * An J, * Jiang X.

Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. yangliutcm

OBJECTIVE: To observe the effect of Tribulus terrestris extract on melanocyte stimulating hormone (MSH) expression in C57BL/6J mouse hair follicles, and investigate the role of Tribulus terrestris extract in activation, proliferation, epidermal migration of dormant hair follicle melanocytes.
METHODS: The aqueous extract of Tribulus terrestris was administered orally in specific pathogen-free C57BL/6J mouse at the daily dose equivalent to 1 g/1 kg in adult human, and the expression and distribution of MSH in the mouse hair follicles was observed with immunohistochemistry.
RESULTS: The positivity rate of MSH expression in the hair follicle melanocytes was 75% in mice treated with the extract, significantly higher than the rate of only 18.75% in the control group (P<0.01).
CONCLUSION: The aqueous extract of Tribulus terrestris can significantly increase MSH expression in the hair follicle melanocytes by activating tyrosinase activity and promoting melanocyte proliferation, melanine synthesis, and epidermal migration of dormant melanocytes.

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