Inflammation and Fibrosis conclusively indentified as causitive in the onset and eventual destruction of the hair follicle seen in Androgenetic Alopecia

This just published study features the integral role that both inflammation and fibrosis play in AGA. It implies that the role played by inflammation and fibrosis is more central to hair loss than the hormonal initiators, namely DHT and Androstenedione.

Androgenetic alopecia in males: a histopathological and ultrastructural study

J Cosmet Dermatol. 2009 Jun;8(2):83-91.

Androgenetic alopecia in males: a histopathological and ultrastructural study.
El-Domyati M, Attia S, Saleh F, Abdel-Wahab H.

Department of Dermatology, Faculty of Medicine, Al-Minya University, Al-Minya,

Background Androgenetic alopecia is a common cosmetic hair disorder, resulting from interplay of genetic, endocrine, and aging factors leading to a patterned follicular miniaturization. Microinflammation seems to be a potential active player in this process. Aims To study the histopathological and ultrastructural changes occurring in male androgenetic alopecia (AGA). Patients/methods Fifty-five subjects were included in this study (40 with AGA and 15 as normal age-matched controls). Skin biopsies from frontal bald area and occipital hairy area were subjected to histopathological examination, immunohistochemical staining for collagen I and ultrastructural study. Results The frontal bald area of patients showed highly significant increase in telogen hairs and decrease in anagen/telogen ratio and terminal/vellus hair ratio (P < 0.001). Perifollicular inflammation was almost a constant feature in early cases and showed a significant inverse correlation with perifollicular fibrosis (P = 0.048), which was more marked with thickening of the follicular sheath in advanced cases. Conclusion Follicular microinflammation plays an integral role in the pathogenesis of AGA in early cases. Over time, thickening of perifollicular sheath takes place due to increased deposition of collagen, resulting in marked perifollicular fibrosis, and sometimes ends by complete destruction of the affected follicles in advanced cases.

Editor's Comment

      Fortunately the destruction of the hair follicle that is caused by fibrosis noted in advanced cases of AGA can be readily avoided through the usage of the amino acid Taurine. In a prior update some time ago we featured a Green Tea Extract/Taurine/Grape Seed Extract based oral supplement for women’s hair loss developed in a joint venture by L’Oreal and Nestle who formed a subsidiary ( Inneov) for the purpose of marketing this hair loss treatment, called “Hair Mass” in the European Union .

      Corporate giants such as L’Oreal and Nestle are not likely to fund patents and research teams, and create joint ventures unless something has a reliable track record.

      In reviewing the many studies done on supplemental Taurine and its effects on fibrosis at various sites in the body, ALL have come back with positive results. Given the pivotal role fibrosis plays in hair follicle miniaturization, their research into its effects on hair growth and the development of a Taurine based hairloss treatment comes as no great surprise.

      Hair Mass is also available now in the U.S. in certain salons under the name “Densitive.”

      The consumer feedback on the efficacy of Hair Mass has been largely positive.

      The Densitive product description from L'Oreal is as follows:

Kerastase Nutrients Densitive 60 Tablets Daily Anti Hair Thinning, Anti Hair Loss Dietry Supplement part of Kerastase Hair Products for people who suffer from daily hair loss or have thin hair.

Take 2 tablets a day with a meal, for at least 3 months (6 months for best results). Ensure at least 3 hours between consumption of Densitive and iron supplements, to optimize the body's intake of the ingredients.;

Key Ingredients:
• Taurine
• Green Tea and Grape Seed Polyphenols
• Zinc

Supplement Facts:
Serving Size 2 Tablets
Servings Per Container 30

Amount Per Serving

Zinc (as zinc gluconate) 15 mg.
Green Tea (Leaf) Extract 375 mg.
Grape Seed Extract 150 mg.
Taurine 150 mg.

Dietary Supplement for people who suffer from daily hair loss or have thin hair that lacks vitality.

Hair Mass helps maintain the stability of the hair bulb, to encourage the production of thicker, denser, and shinier hair.

Results demonstrated in clinical studies:

1. Anti Hair Loss Efficacy: significant hair loss reduction observed.

2. Hair Thickening Efficiency: visible improvement noted in hair.

Editor's Comment

Densitive sells for $ 60.00 U.S. and lasts for 30 days.

You can easily put a more potent, bioavailable, higher milligram equivilant for a fraction of the cost. Compare a one month supply brand name Densitive with the following:

OptiZinc (90 capsules) 30 mg.
Mega Green Tea Extract ( 98% polyphenols, 326.25mg EGCG-100 capsules) 725 mg.
Grape Seed Extract w/Resveratrol (60 capsules) 150 mg.
Taurine (50 capsules) 1000 mg.

OptiZinc costs $8.95 US or less than $3.00 a month.

Mega Green Extract costs $28.00 US or about $9.34 a month.

Grape Seed Extract w/Resveratrol costs $36.00 US or $18.00 a month.

Taurine costs $8.95 US or about $5.00 a month.

Total monthly costs for the significantly more potent Densitive/Hair Mass equivilant is $35.34.

Being in the United States has its advantages and disadvantages in terms of hair loss treatment. The most significant disadvantage is that the FDA and pharmaceutical industry function as barriers to innovative treatment progress from smaller firms and research teams. A distinct advantage is that supplements and nutraceuticals are generally much less costly than in Europe and Japan. This is clearly reflected in the cost differentials between Hiar Mass/Densitive and Capsures(Resveratrol/Curcumin) and their more potent, equivilant ingredient counterparts in the US.

Related Articles:

Vitamin D and L-Taurine

L'oreal patents an oral hairloss treatment

Nestle and L’Oreal Launch a New Taurine Based Pill for Hairloss

More Evidence for Taurine

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