Low Dose Resveratrol For Health and Hair
As you may already know, Italian researchers identified the hair growth stimulating effects of a relatively low dose of a combination of Resveratrol and Curcumin , and market it in Europe as a treatment for MPB, under the name Capsures.
We have been recommended this combination since this patent was published and have gotten uniformly positive feedback that is consistent with the data that was presented in the patent application. For more information on the specifics of that can be found here: Italian Patent Details Hair Growth Effects of Resveratrol/Curcumin Combination
You have probably heard about the at times hyped, multiple anti-aging, health promoting effects of Resveratrol (the active constituent in Red Wine) for several years now.
Cell studies have produced no less than consistently astounding results on a number of fronts from various age related disease treatments, and cancer chemoprevention/treatment.
Dr. Sanjay Gupta, who you may know as a health commentator on CNN, identified Resveratrol as the singularly most promising anti-aging agent to date in his book ,” Life Chasers.”
There have, however been questions about the implications its' apparent low oral bio-availabilty. Fortunately, studies with orally administered Resveratrol to mammals, at doses readily obtainable in humans, and human studies are beginning to come in, consistently showing benefits.
Caloric restriction, and in two studies, Resveratrol, have thus far been the only methods that has produced significant gains in maximum life span. Some of the most intriguing news has been studies showing Resveratrol produces the same effects on health and genetic aging markers as caloric restriction, without having to actually restrict calories.
What might all this mean for hair growth or hair retention???
Calorie restricted mice in all studies, in addition to outliving the controls, without exception, maintained full thick coats of fur compared to controls, who were fed a normal diet. A reasonable implication for Resveratrol is that it will likely produce similar effects on hair as it relates to age related or senescent,(not Androgenetic) thinning
Hair that diffusely thins with the aging process is often juxtaposed on existing hormone related hair loss, making a bad situation worse. The exact mechanisms by which caloric restriction or likely Resveratrol, would prevent this, be it inhibition of age related atherosclerosis, or other factors, remain unclear.
A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice
Jamie L. Barger, Tsuyoshi Kayo, James M. Vann, Edward B. Arias, Jelai Wang, Timothy A. Hacker, Ying Wang, Daniel Raederstorff, Jason D. Morrow, Christiaan Leeuwenburgh, David B. Allison, Kurt W. Saupe, Gregory D. Cartee, Richard Weindruch, Tomas A. Prolla
Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg−1 day−1), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR.
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