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Dr. Sawaya, Miami Research Team, Discover New Target Mechanism for Hair Loss.
Dr. Marty Sawaya, an imminent researcher in the treatment of Androgenetic Alopecia, along with a research team from the University of Miami, have made a discovery involving the auto-immune,inflammatory component of hair loss that they contend may provide a basis for novel treatments of Androgenetic Alopecia. Caspase 1 is known as an inflammasome that activates auto-immune, inflammatory responses. As novel as this "discovery" may seem, L'Oreal was on to this several years ago, and addressed this inflammasone in both their oral hair loss treaments, "Hair Mass for Men" and "Hair Mass for Women." "
This University of Miami research team found that levels of Caspase 1 are significantly higher in men with pattern hair loss, and are much lower, similar to normal, in non-balding controls, and in men taking Propecia,(Finasteride). As you may know, in male and female pattern baldness, the autoimmune, inflammatory response, and eventual fibrosis in the hair follicles that is initiated by DHT is more primary to hair miniaturization and eventual balding, NOT DHT itself.
Caspase-1 Level Is Higher in the Scalp in Androgenetic Alopecia.
de Rivero Vaccari JP, Sawaya ME, Brand F 3rd, Nusbaum BP, Bauman AJ, Bramlett HM, Dietrich WD, Keane RW.
Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida.
BACKGROUND AND OBJECTIVES:
Inflammasomes that activate caspase-1 govern the innate immune inflammatory response. Whether hair loss associated with androgenetic alopecia (AGA) involves caspase-1 activation is not known.
Immunohistochemical staining for caspase-1 was performed on scalp tissue sections, and protein lysates were analyzed from individuals with AGA (no treatment), and individuals with AGA taking finasteride with apparent hair growth, individuals with AGA taking finasteride without noted hair growth, and normal controls. In vitro studies of human keratinocytes were conducted to establish effects of finasteride, dihydrotestosterone (DHT), and testosterone on caspase-1 levels using immunoblot analysis.
Caspase-1 is expressed in normal human adult epidermal keratinocytes. Caspase-1 expression is greater in men with AGA. In contrast, in men taking finasteride, caspase-1 levels were lower and were similar to those in normal controls. In vitro studies showed that keratinocytes treated with finasteride in combination with testosterone or DHT resulted in a significant decrease in caspase-1 expression.
In vivo and in vitro finasteride treatment resulted in lower caspase-1 expression, supporting the idea that androgens influence innate immunity involved in the hair cycle in AGA. These findings may provide a basis for development of novel treatments for inflammatory skin and hair diseases.
Drastically lowering blood levels of DHT with the usage of either Avodart or Propecia is a rather crude, side effect prone way of reducing Caspase 1, and this inflammation. The problem is that DHT does much more in the body than simply cause hair loss and enlarge Prostate glands. DHT also is needed for mood modulation, cognitive, and various aspects of sexual function. Pharmaceutical 5 alpha reductase inhibitors like Propecia and Avodart are very efficient at lowering DHT for long sustained periods, and are, in their generic forms, very cost effective. The problem is the high price tag in terms of side effects. If you are on either one and don’t feel you are having any side effects, go off for about 3 weeks and see how much better you all of a sudden feel.
Evidently, the research team at L’Oreal/Nestle/Inneov, whose patented oral hair loss treatment formulas, Hair Mass and Hair Mass for Men were apparently already addressing of this Caspase 1 connection to treating hair loss, and use two primary constituents in both formulas to specifically reduce its expression; Green Tea Extract and the free form amino acid, Taurine. The aforementioned study on Caspase 1 and hair loss may generate some pharmaceutical intervention that reduces its expression, either locally or systemically. Inneov’s formula, Hair Mass, already does this and provides multiple cross over anti-aging and health benefits.
Four month before and after pictures using L'Oreal's "Hair Mass for Men" (Taurine, Green Tea, Grape Seed Extract, Zinc, Beta-Sitosterol)
Week 1 Week 16
Week 1 Week 16
Week 1 Week 16
Green tea polyphenol epigallocatechin-3-gallate suppresses melanoma growth by inhibiting inflammasome and IL-1β secretion
Lixia Z. Ellisa, Weimin Liua, Yuchun Luoa, Miyako Okamotoa, Dovina Qua, Jeffrey H. Dunna,
Department of Dermatology, University of Colorado School of Medicine, Aurora, CO 80045, USA
Epigallocatechin-3-gallate (EGCG), the major polyphenolic component of green tea, has been demonstrated to possess anti-inflammatory, antioxidant, anti-mutagenic and anti-carcinogenic properties. The anti-melanoma effect of EGCG has been previously suggested, but no clear mechanism of action has been established. In this study, we demonstrated that EGCG inhibits melanoma cell growth at physiological doses (0.1–1 μM). In the search for mechanisms of EGCG-mediated melanoma cell suppression, we found that NF-κB was inhibited, and that reduced NF-κB activity was associated with decreased IL-1β secretion from melanoma cells. Since inflammasomes are involved in IL-1β secretion, we investigated whether IL-1β suppression was mediated by inflammasomes, and found that EGCG treatment led to downregulation of the inflammasome component, NLRP1, and reduced caspase-1 activation. Furthermore, silencing the expression of NLRP1 abolished EGCG-induced inhibition of tumor cell proliferation both in
vitro and in vivo, suggesting a key role of inflammasomes in EGCG efficacy. This paper provides a novel mechanism for EGCG-induced melanoma inhibition: inflammasome downregulation → decreased IL-1β secretion → decreased NF-κB activities → decreased cell growth. In addition, it suggests inflammasomes and IL-1β could be potential targets for future melanoma therapeutics.
Dietary taurine reduces retinal damage produced by photochemical stress via antioxidant and anti-apoptotic mechanisms in Sprague-Dawley rats.
Yu X, Chen K, Wei N, Zhang Q, Liu J, Mi M.
Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China.
Taurine has been shown to be tissue protective in many models of oxidant-induced injury. However, its protective role against retinal damage induced by photochemical stress is less well known. The purpose of the present study was to investigate whether dietary taurine reduced retinal photochemical damage in Sprague-Dawley rats and to further explore the underlying molecular mechanisms of this action. Twenty rats fed AIN-93 formulation and maintained in the dark for 48 h were used as controls (n 20). Another forty rats were randomly divided into two groups and then treated with (n 20) or without 4 % taurine (n 20) for 15 d respectively. After treatment, these two groups were exposed to fluorescent light (3000 +/- 200 lux and 25 degrees C), and the protective effects of dietary taurine were then evaluated. The present results showed that dietary taurine effectively prevented retinal photochemical damage as assessed by changes of morphology. Also, the supplementation caused an increase of taurine in the retina, a decrease of malondialdehyde (P < 0.01), and elevation of superoxide dismutase (P < 0.01) and glutathione peroxidase activities in the retina (P < 0.01). Moreover, dietary taurine inhibited activator protein-1 (AP-1) (c-fos/c-jun subunits) expression (P < 0.05), up regulated NF-kappaB (p65) expression (P < 0.05), and decreased caspase-1 expression (P < 0.05) so as to reduce the apoptosis of photoreceptors in the retina (P < 0.05). These results suggest that dietary taurine reduced retinal damage produced by photochemical stress via antioxidant and anti-AP-1-NF-kappaB-caspase-1 apoptotic mechanisms in rats.
This study reinforces what was found by researchers at L’Oreal: that dietary supplemental Green Tea Extract combined with Taurine has significantly positive effects on hair growth and hair loss prevention, (curiously, topically applied Taurine had no ascertainable effect).
These touted “new” findings about Caspase 1 and its role in hair loss, by a prestigious team of researchers at the University of Miami, serve to further reinforce our ongoing recommendation for the usage of Green Tea and Taurine as a viable Androgenetic hair loss intervention.
Hair Mass and Hair Mass for men may either be purchased from Europe or formulated at a significantly lower cost and higher potency by combining Mega Green Tea Extract (326.25 mg, EGCG), Taurine, Grape Seed Extract, and Zinc at a fraction of the cost.