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Supplements for Hair Growth Validated in New Study
A new multi-component hair growth supplement, has been shown to stimulate hair growth in those with Androgenetic Alopecia in a just published study. In evaluating the active ingredients of this formula, it contains only very modest doses of a few of our recommendations in our treatment protocol, and was still potent enough to induce hair growth. He active ingredients in this formulation Forti5, obtained in the full text of the study, are; Vitamin D (cholecalciferol)-200 iu, Beta Sitosterol -100mg, Soy Isoflavones 40% Extract- 300mg, Green Tea Extract 75% -250mg, Omega 3 and 6 -150mg, Melatonin-3mg.
Here is the just published abstract:
J Clin Aesthet Dermatol. 2017 Feb;10(2):52-56. Epub 2017 Feb 1.
An Open-Label Evaluator Blinded Study of the Efficacy and Safety of a New Nutritional Supplement in Androgenetic Alopecia: A Pilot Study.
Nichols AJ, Hughes OB, Canazza A, Zaiac MN.
Objective: To evaluate the effectiveness of a novel oral supplement, Forti5, containing green tea extract, omega 3 and 6 fatty acids, cholecalciferol, melatonin, beta-sitosterol, and soy isoflavones, and in the management of subjects with androgenetic alopecia. Design: A prospective case series of 10 subjects. Setting: Open-label, evaluator-blinded, proof-of-concept study. Participants: Ten adult subjects with androgenetic alopecia completed the study. Subjects were not allowed to use oral or topical hair growth products in the 24 weeks preceding the study or during the study. The nutritional supplement was administered at a dosage of two tablets daily for 24 weeks. Measurements: Clinical evaluations were performed at baseline and at 24 weeks. Efficacy was evaluated using hair mass index measured by cross section trichometer, terminal hair count measured with dermoscopy and Investigator Global Photography Assessment. Results: Overall 80 percent of subjects (8/10) were rated as improved after 24 weeks of supplementation (mean change of +1.4 equivalent to slightly-to-moderately increased). Forty percent of subjects (4/10) were rated as moderately improved (2+), and 10 percent (1/10) were rated as greatly improved (3+). There was a significant improvement in terminal hair count (mean increase of 5.9% or 4.2 more terminal hairs in the area examined, p=0.014) and in Hair Mass Index (mean increase of 9.5% or 4.5 higher Hair Mass Index, p=0.003). Conclusion:
These preliminary results indicate that Forti5 a novel nutritional supplement that contains cholecalciferol, omega 3 and 6 fatty acids, melatonin, antioxidants, and botanical 5-alpha reductase inhibitors, may be a useful in the treatment of androgenetic alopecia.
Again, even the low doses used where enough to produce hair growth. Each of the active ingredients have identified mechanisms that support hair growth:
Inflammatory messengers (cytokines) cause shedding and hasten the course of hormonal hair loss.
Melatonin:stimulates pigmentation and hair growth, Forti5: 3mg,
Our recommendation 3-10mg, only at night
The hair follicle in the anagen phase locally produces melatonin to ameliorate apoptosis and for cyto-protection
Melatonin stops shedding (telogen) as it inhibits apoptosis in Hair Follicle keratinocytes
Helps reduce stress-related hair loss. Melatonin shields follicles from endogenous stressors associated with elevated cortisol
Melatonin is an especially effective antioxidant that can facilitate DNA repair mechanisms
Melatonin down regulates androgen receptor activity
Vitamin D (Cholecalciferol) Forti5:
200 iu, Our Recommendation 5000 iu
Vitamin D3 regulates growth and differentiation of keratinocytes
Vitamin D knockout mice exhibit alopecia shortly after birth
Vitamin D receptors facilitate transcription of follicle genes
Deficiencies in Vitamin D, which is endemic in Western Cultures accelerate the aging phenomena, including Hair Loss
Vitamin D deficiency is correlated with hair loss
Although we have yet to recommend Vitamin D and/or Melatonin as part of our treatment protocol, we feel their inclusion in any regime is warranted. Using Vitamin D at a much higher dose than a mere 200 iu would be indicated to get any ascertainable benefit on hair growth. 5000iu are recommended for most people to obtain any healthy response. 3 mg of Melatonin is OK, but you could go much higher, ie 10mg. Be sure to take Melatonin at night only.
In addition to the ingredients used in Forti5, there is much more you can do, both topically and systemically to more aggressively reverse the course of MPB (AGA). Here are some more useful recommendations along with their identified mechanisms and rationale: Our Updated Protocol
To consult with our Hairloss Expert in person about the most advanced hair loss treatment protocols, call toll free: 1-888-577-HAIR(4247), (321)733-5933 9-9PM EST Or E-mail us at MPBResearch@aol.com
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These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product, label or packaging. You should not use the information on this site for diagnosis or treatment on any health problem or for prescription of any medication or other treatment. You should consult with a health care professional before starting any diet, exercise, or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without consulting your physician.
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