Emerging Model for Androgenetic Alopecia
Androgenetic Alopecia (AGA, MPB) begins when DHT causes the hair follicle to be read as a “foreign body”. Your immune system then gradually, over time, rejects the hair follicle, resulting in peri-follicular inflammation and eventual fibrosis. The main damage in pattern hair loss is predominantly inflammation mediated. Damage to the lining of blood vessels, which produces hair growth factors, ensures the progression of the balding process. Traditional, and more recently developed, hair growth stimulants specifically target these blood vessel lining produced hair growth factors.
• Hormonal Mechanisms:
Castration, reduction of DHT levels, and androgen receptor antagonism, all, to varying degrees block the progression of balding and hair loss. However, women and castrated males have other sources of androgens and can still experience pattern loss.
• Inflammatory/Immunological Mechanisms:
On a cellular level, AGA resembles organ rejection. A greater number of immune system cells cluster around the base of the scalp hair follicle.
• Interestingly, organ rejection drugs such as cyclosporin treat balding better than anti-androgens, but they are impractical for sustained usage. Hair Follicle Antibodies are evident in the majority of those with pattern hair loss.
Blood Vessel Linings in Male and Female Pattern Hair Loss
Rogaine (Minoxidil), and several other compounds mimic hair growth factors (nitric oxide radical, etc.) generated by blood vessel linings. In atherosclerosis, and the chronic inflammation seen in MPB, production of these hair growth factors precipitously decline. Atherosclerosis is associated epidemiologically with senescent or age related hair loss.
An appropriate therapeutic target for hair growth is the nitric oxide/superoxide system.
Dr Peter Proctor MD, PhD has been on the forefront of developing topical hair loss treatments that specifically focus on these hair growth factors.
Peter H. Proctor, PhD, MD is an American pharmacologist, toxicologist, biophysicist and physician. He has worked in neuroscience and biological psychiatry, organic electronics, pharmacology/toxicology, as well as free radical and oxidative stress research. He pioneered aspects of redox signaling, which is the concept that reactive oxygen species, other electronically activated molecules, and solid-state electronic processes are involved in cell signaling.
He also holds pharmaceutical patents, e.g., for the use of nitrone and nitroxide drugs in the treatment of radiation dermatitis and alopecia, as well as (among other indications) fibrocystic disease of breast and neuropathic pain. Some of his drugs are currently in clinical trials.
His treatments are unique in their ability target nitric oxide/superoxide systems. mechanisms. Although components of his topical formulation and shampoo share some of the core technology of Rogaine, (Minoxidil), they are far more potent, and don’t produce the dramatic shedding upon cessation of usage as is often the case with Rogaine.
We have recommended his hair growth stimulating topical treatment and shampoo for years as part of a multi-pronged hair loss treatment approach that also incorporates anti-DHT and anti-inflammatory components.
Dr. Proctor’s Advanced Thinning Hair Formula is a topical formulation of many of the nonprescription hair-loss treatment agents coming out of our screening program. These include various SODases, copper-binding peptides, and pyridine-N-Oxide hair growth stimulators.
Dr Proctor’s Thinning Hair Shampoo contains the minoxidil-like hair growth stimulator NANO (nicotinic acid N-Oxide). In addition, this shampoo contains a SODase-type hair growth stimulating agent. Dr Proctor’s Thinning Hair Shampoo can be used as a stand alone treatment in the beginning stages of hair loss, and is an excellent adjuvant treatment for Dr. Proctor’s Thinning Hair Formula.
Since Dr. Proctor’s Thinning Hair Shampoo is effective even when used 2-3 times a week, many alternate it with either Nizoral Shampoo or a Piroctone Olamine shampoo such as Folicure para Caspa, to get the hair growth benefits of both.
As with other topical treatments, the efficacy of any topical treatment can be significantly enhanced by the co-adminstration of Emu Oil.
To optimize the benefits of Dr Proctor’s Advanced Thinning Hair Formula apply Emu Oil 5-10 minutes after. Doing so will carry it all the way through the 7 layers of dermis and increase the residence time of the active ingredients.