5 alpha Reductase (5AR) is the enzyme that converts testosterone into dihydrotestosterone (DHT). DHT has been conclusively implicated in the pathogenesis of MPB, Acne, Hirsutism and Prostate Enlargement, which are generally referred to as “Androgen Mediated” disorders. Lowering DHT levels to a point in humans will over time, reliably halt and to some degree, reverse the course of MPB. Reducing DHT levels can be readily accomplished by inhibiting the enzyme 5AR, which is the mechanism of action for both Propecia (finasteride) and Avodart (dutasteride). Both Propecia and even more so, Avodart, are established to have fairly reliable hair growth effects. Unfortunately both come with a side effect price tag, including loss/reduction of libido, erectile dysfunction, depression, insomnia, and anxiety. Post Finasteride Syndrome is a newly coined diagnosis for symptoms of reduced libido and erectile dysfunction that persist years after discontinuation of these 5AR inhibiting drugs. It is however possible to inhibit 5AR in a way that is not only side effect free, but in a way that actually enhances both mood and male function. A team of researchers found in 3 successive (abstracts below) studies, 2 published in the prestigious Journal of the International Society for Sports Nutrition, that the combination of Astaxanthin with Saw Palmetto achieved a 98% inhibition of 5 alpha reductase.
J Herb Pharmacother 2005;5(1):17-26.
J Int Soc Sports Nutr2008 Aug 12;5:12. An open label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males AbstractBackground: Maintaining endogenous testosterone (T) levels as men age may slow the symptoms of sarcopenia, andropause and decline in physical performance. Drugs inhibiting the enzyme 5alpha-reductase (5AR) produce increased blood levels of T and decreased levels of dihydrotestosterone (DHT). However, symptoms of gynecomastia have been reported due to the aromatase (AER) enzyme converting excess T to estradiol (ES). The carotenoid astaxanthin (AX) from Haematococcus pluvialis, Saw Palmetto berry lipid extract (SPLE) from Serenoa repens and the precise combination of these dietary supplements, Alphastat(R) (Mytosterone(trade mark)), have been reported to have inhibitory effects on both 5AR and AER in-vitro. Concomitant regulation of both enzymes in-vivo would cause DHT and ES blood levels to decrease and T levels to increase. The purpose of this clinical study was to determine if patented Alphastat(R) (Mytosterone(trade mark)) could produce these effects in a dose dependent manner.
J Int Soc Sports Nutr2014 Aug 23;11:43. Evaluation of Resettin® on serum hormone levels in sedentary males AbstractBackground: Comparisons of hormones such as dihydrotestosterone (DHT), estradiol (E2), and testosterone indicate their impact on metabolism and body composition. While less is known regarding DHT and E2, testosterone is an androgenic metabolic hormone capable of positively regulating a variety of anabolic and androgenic processes in the body. Accordingly, it has been postulated that the age-related reduction in serum testosterone levels leads to reductions in lean muscle mass, bone mineral density, and other physical conditions that impair physical performance and decrease quality of life. Preliminary studies suggest that key ingredients found in Resettin®/MyTosterone™, a natural supplement containing the carotenoid astaxanthin from Haematococcus pluvialis and Saw Palmetto berry lipid extract from Serenoa repens, could positively impact testosterone levels. To investigate the clinical efficacy of Resettin®, the serum profiles of testosterone, E2 and DHT in healthy sedentary males before and after Resettin® treatment were evaluated in a randomized, placebo controlled clinical trial.
The combination used in these was also patented and trademarked (Resettin) as both a Prostate Treatment and an endocrine modulating intervention for aging males, who progressively become more androgen deficient. It reduces DHT and Estrogen, but which become more elevated in men in what is considered “normal” aging. If that weren’t enough, it also increases testosterone to a high normal level which many androgen deficient middle aged men can only attain through either testosterone patches or injections.
Astaxanthin also helps reduce wrinkling, maintain skin firmness, and protect from ultra violet light insult from the inside out.
I have been using the combination of Saw Palmetto/Beta sitosterol and Astaxanthin (4 mg.) for over 10 years, and have a high testosterone level along with a low level of bodyfat. Although I use numerous other supplements for anti-aging, health and hair, this is one core combination with unique effects on Testosterone, Estrogen and DHT I would not do without, especially since going off Propecia over a decade ago.
Due to its unique mechanisms, this combination has reportedly been used in conjunction with Propecia (finasteride) and Avodart (dutasteride) to both accentuate their hair growth effects and mitigate side effects.
This combination simply consists of one soft gel each of both Astaxanthin and Palmetto Guard. Our Astaxanthin is compounded with phospholipids for significantly enhanced absorption. Palmetto Guard combines the standardized critical CO2 extract of Saw palmetto AND Beta-Sitosterol, which in addition to inhibiting 5 alpha reductase, inhibits androgen binding at receptor sites. Both are low cost and easily integrated into any existing regime.