We previously posted an update that featured the work and patent data of an Italian research team that detailed the hair growth effects of an oral Resveratrol/Curcumin combination, subsequently patented and named “Capsures.” In follow up research they also found that this combination has beneficial effects for stress related hair loss in addition to Androgenetic hair loss due to its effects on Substance P and the Cannabinoid receptors.
This study independently confirms their previously posited mechanisms on why Resveratrol and Curcumin constitute such a boon for hair growth and hair loss treatment. Of note is that the oral combination of Soy Isoflavones and Cayenne Pepper appear to function similarly to Resveratrol/Curcumin, with this particular mechanism in common, with variations in other mechanisms on hair growth. Given our aggressive orientation in treating hair loss, we recommend using both, admitting it does take some degree of discipline to stay regular with Cayenne Pepper consumption.
The feedback we’ve been getting on both combinations has thus far been positive and consistent with the results reported in the published studies and patent registry.
J Pharmacol Exp Ther. 2009 Apr 9.
The dietary polyphenols trans-resveratrol and curcumin selectively bind human CB1 cannabinoid receptors with nanomolar affinities and function as antagonists/inverse agonists.
Seely KA, Levi MS, Prather PL.
University of Arkansas for Medical Sciences.
The dietary polyphenols trans-resveratrol (found in red wine) and curcumin (found in curry powders) exert anti-inflammatory and anti-oxidant effects via poorly defined mechanisms. Interestingly, cannabinoids, derived from the marijuana plant (Cannabis sativa), produce similar protective effects via CB1 and CB2 receptors. We examined whether trans-resveratrol, curcumin and ASC-J9 (a curcumin analog) act as ligands at cannabinoid receptors. All three bind to hCB1 and mCB1 receptors with nanomolar affinities, displaying only micromolar affinities for hCB2 receptors. Characteristic of inverse agonists, the polyphenols inhibit basal G-protein activity in membranes prepared from CHO-hCB1 cells or mouse brain, that is reversed by a neutral CB1 antagonist. Furthermore, they competitively antagonize G-protein activation produced by a CB1 agonist. In intact CHO-hCB1 cells, the polyphenols act as neutral antagonists, producing no effect when tested alone, while competitively antagonizing CB1 agonist mediated inhibition of adenylyl cyclase activity. Confirming their neutral antagonist profile in cells, the polyphenols similarly attenuate stimulation of adenylyl cyclase activity produced by a CB1 inverse agonist. In mice, the polyphenols dose-dependently reverse acute hypothermia produced by a CB1 agonist. Upon repeated administration, the polyphenols also reduce body weight in mice similar to that produced by a CB1 antagonist/inverse agonist. Finally, trans-resveratrol and curcumin share common structural motifs with other known cannabinoid receptor ligands. Collectively, we suggest that trans-resveratrol and curcumin act as antagonists/inverse agonists at CB1 receptors at dietary relevant concentrations. Therefore, these polyphenols and their derivatives might be developed as novel, non-toxic CB1 therapeutics for obesity and/or drug dependence.