Several studies have confirmed that both Androgenetic and Senescent (age related) thinning of hair are characterized by diminished micro-circulation to the hair follicles. Maintaining this circulation is key to hair follicle health, and preventing the inflammation induced miniaturization of the follicle seen in Androgenetic hair loss. Independent of hormonal factors there is an overall reduction in hair shaft diameter seen with advanced age. Age related thinning gives even full heads of hair that are unaffected by pattern hair loss, a see through, wispy look.
One recent study conducted in Japan suggested blood circulation in the scalps of young men diagnosed with male pattern baldness was almost 2.6 times lower than in those of the control group.
In a prior update we extensively addressed the issue of diminished micro-circulation, its relationship to Androgenetic (hormonal) and Senescent hair loss, and how hair growth can be restored with specific circulation enhancing supplements such as Ginko Biloba Extract, Bilberry Extract, Grape Seed Extract and the pharmaceutical Tentral, (theophylline).
Circulation is Implicated in Hair Loss
Ginko Biloba 24% Extract at a dose of 120 mg-240 mg/day, has been one of our long standing primary recommendations for cognitive enhancement and age related, senescent thinning , and an adjunctive recommendation for Androgenic hair loss. The following just published study found favorable effects of Ginkgo on hair growth in mammals.
Biofactors. 2019 Sep 14. Ginkgolide B and bilobalide promote the growth and increase β-catenin expression in hair follicle dermal papilla cells of American minks.AbstractThe regeneration of proliferation potential of dermal papilla (DP) cells contributes to the treatment of hair loss disorders. Ginkgolide B (GKB) and bilobalide (BB) are two functional components isolated from Ginkgo biloba that can promote hair growth. In the current study, the effect of GKB or BB on DP cell viability and the related signaling was assessed. Hair follicles were isolated from minks, and the growth of hair follicles was measured under the administration of GKB or BB. DP cells isolated from minks were also subjected to GKB or BB. The administration of GKB or BB induced the growth of hair follicles. The viability of DP cells was also increased by GKB or BB as illustrated by methyl thiazolyl tetrazolium and flow cytometry detection. Moreover, the secretion of VEGF was enhanced by GKB or BB. At molecular level, the activities of Akt, ERK1/2, and β-catenin were induced by GKB, whereas BB only increased the activities of Akt and β-catenin. In conclusion, although the two components influenced the β-catenin signaling activity in distinct mechanisms, they both increased the viability of DP cells and promoted the cycle of hair follicles.
Ginkgo Biloba is one of the oldest trees known and has been used to increase peripheral circulation for nearly 2,800 years. Ginkgo has been found to:
- Support healthy circulation
- Help maintain the normal function and tone of blood vessels
- Support healthy oxygen and glucose metabolism in the brain
- Stabilize capillaries and make them less fragile
- Support normal coagulation of blood
- Support healthy aging in the brain
- Increase hair growth
Ginkgo leaf extracts contain several active constituents with neuroprotective and cardioprotective properties. These include flavonoids (e.g., rutin, quercetin, kaempferol, and proanthocyanidins), terpenoids (i.e., ginkgolides), and organic acids. Flavonoids are known to strengthen capillaries, promote healthy blood flow to the brain, and help maintain cognitive health.
Ginkgo Biloba Extract is a remarkably cost effective, which at a dose of 120 mg/day, cost less than $4.00 a month.
Topically applied Emu Oil, due to its high eicosanoid content also increases blood flow and oxygenation on a cellular level. Emu Oil contains compounds called eicosanoids, Eicosanoids facilitate cell permeability which causes greater oxygen uptake.
Adenosine, a topical compound that was found to be significantly superior to 5% Minoxidil, in a study with 55 subjects, functions as an ATP (Adenosine Triphosphate) precursor. ATP is the primary carrier of energy in cells.
Ginkgo supplementation increases cellular energy, as it supports the cells’ healthy production of adenosine triphosphate (ATP).
Emu Oil contains high levels of ATP (adenosine triphosphate) which may partially account for one of the many multiple mechanisms by which it stimulates hair growth.
Despite the outdated dogma in the American allopathic medical community, that takes the position that circulation has nothing to do with Androgenic hair loss, there is ample evidence to the contrary.
Addressing circulation in one’s hair loss treatment regime will occasionally be sufficient by itself to resolve the issue, but is generally advised by us as one component in a protocol that optimally addresses not only circulation, but androgens and inflammation as well.