Resveratrol Inhibits DHT-inducible IL-6, Curcumin, an extract of Tumeric, has been shown to counter Androgenetic hair loss via several mechanisms. It has been shown to have profound anti-inflammation properties, and promote a healthy inflammatory response. In Androgenetic Alopecia, DHT, in those genetically predisposed, initiates an exaggerated inflammatory response on the affected hair follicles in the pattern area, resulting in miniaturization and eventual fibrosis. Curcumin, taken in sufficiently high doses, has resolved hair loss for many as a standalone supplement. It’s beneficial effects on hair loss have always been assumed to be associated with its anti-inflammatory properties, which is understandable, given Curcumin inhibits TGF-b, transcription factor NF-kB, which downregulates the inflammatory cytokines TNF-α and interleukin 1 which are established to cause progressive miniaturization of hair follicles.
Androscience, a San Diego based Biotech company, has found specific isolates of Curcumin that inhibit 5 alpha reducatse, and have filed for patents for their use as treatments for both acne and Androgenetic Alopecia.
This just released study demonstrates that Curcumin itself strongly inhibits 5 alpha reductase, which is great news for anyone who was anticipating the eventual availability of these patented isolates.
Anal Bioanal Chem. 2020 Mar;412(7):1685-1692. doi: 10.1007/s00216-020-02408-y. Epub 2020 Feb 1.
Fully automated chip-based nanoelectrospray ionization-mass spectrometry as an effective tool for rapid and high-throughput screening of 5α-reductase inhibitors.
Zheng R1, Li L1, Deng X1, Tian M1, Wang Z2, Yang L3,4.
The 5α-reductase converts testosterone to dihydrotestosterone (DHT), and excess DHT could cause androgen-related diseases such as androgenetic alopecia and benign prostatic hyperplasia (BPH). To discover new 5α-reductase inhibitors, effective drug screening method with high throughput is thus essential. In this study, fully automated chip-based nanoelectrospray ionization-mass spectrometry (nano-ESI-MS) was innovatively utilized as a screening tool for 5α-reductase inhibitory assay in direct infusion mode, which simplified sample pretreatment and greatly improved experimental efficiency. The preliminary data indicated that curcumin, a natural anti-inflammatory compound, exhibited notably 5α-reductase inhibition activity. Moreover, the obtained results of the chip-based nano-ESI-MS were well consistent with those of HPLC-MS, which suggested that the chip-based nano-ESI-MS could be treated as a rapid and high-throughput drugs screening strategy in pharmaceutical development. Graphical abstract.