Ancient Indo-Tibetan, Taoist systems
There are both readily available drugs and many in the research pipeline that studies have shown reliably increase both lifespan and health span in animals AND humans. The available ones that I currently use for anti-aging purposes are; Metformin, Rapamycin, and the combination of Dasatinib (an oral leukemia drug) in combination with Quercetin. Metformin I use at a dose of 1500mg a day, and take with my evening meal, as I actually by intermittent fasting design, eat no food until 4-5 pm each day. Metformin modulates a number of cellular and metabolic mechanisms that are conclusively associated with the development of age-related conditions and aging itself.
Rapamycin, an immune modulating drug, has also been demonstrated to have potent anti-aging effects in mammals, including humans. It functions in this way by lowering the activity of the MTOR (mammalian target of Rapamycin) pathway. I use Rapamycin at a dose of 5 mg., 1 x a week. Some yet to be published data indicate that higher doses, e.i.15 mg a week, may produce more robust anti-aging effects.
The other pharmaceutical intervention I use for Anti-aging purposes is the combination of Dasatinib and Quercetin, which functions as a Senolytic, (removes old or senescent cells) In short, senescent cells are damaged cells that permanently withdraw from the cell cycle and secrete inflammatory proteins. They increase with age and wreak havoc on health, and are implicated in age related processes. Intermittent removal of senescent cells has been shown in human studies to have age reversal effects.
I will go into far more detail in upcoming articles regarding the antiaging effects of Metformin, Rapamycin, and the combination of Dasatinib and Quercetin.
Although these interventions are not “approved” for anti-aging purposes, the existing data is compelling enough to warrant taking action now.
If we waited for clinical trials to provide definitive evidence, the field of anti-aging would not exist. If we wait for clinical trials to be concluded it will deprive millions of people of the benefit of senolytics in their own lifetime.
The purpose of this website is to present sufficient data so that patients can make their own informed decision regarding whether to use senolytics now or wait until more is known.