Green Tea/Soy Combination Additional Mechanisms that Benefit Hairloss

This study evaluating the en vivo anti-inflammatory effects in an androgen mediated model of inflammation, of the combination of Green Tea and Soy, bodes well for its effects on the treatment of Androgenetic Alopecia, (AGA)) for several reasons.

One of the most notable is its ability to decrease the protein expression of tumor necrosis factor, an inflammatory messenger that has been termed the ‘Hair Follicle Assassin’ by several researchers. In this study, it was found that the *combination* of Soy and Green Tea, not the singular presence of either, produced these anti-inflammatory effects on androgen mediated inflammation.

Curcumin analogues have also been found to be powerful inhibitors of tumor necrosis factor, explaining in part, its hair growth effects when orally combined with Resveratrol.

An additional cosmetic benefit of Soy Isoflavones has to do with its effects on the retardation of skin aging.Soy Isoflavones used internally are well documented to improve and maintain skin’s firmness and increase skin thickness. They are used in Inneov’s premiere anti skin- aging cosmeceutical, Anti-Age FERMETE. In combination with Lycopene and Vitamin C they found that internally consumed Soy Isoflavones stimulate collagen production by 64%.

As you may know from our previous updates, Inneov uses Green Tea Extract in part because of its anti-inflammatory benefits, in their hair growth formulas for men and women. Internally consumed Green Tea has also been shown in studies to confer a UV protective on skin, important for those with AGA, as it is among other mechanisms, found to be a UV-aggravated dermatosis.

Inneov, the French anti-aging research subsidiary of L’Oreal and Nestle is a company whose developments we monitor and track closely. Their emphasis on usable, evidence based interventions on both hair loss and skin aging is an emphasis we albeit narcissistically, passionately share.

In previous articles and studies the ability of the combination of Soy and Green Tea to lower serum dht , (by an astounding 80%), facilitate Equol production, regulate SHBG, and its implications for the prevention/treatment of AGA were discussed, and are here for your perusal in our featured articles.

J Nutr Biochem. 2010 Aug 27.

Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFkappaB pathway in the Noble rat model.

Hsu A, Bruno RS, L hr CV, Taylor AW, Dashwood RH, Bray TM, Ho E.

Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA.


Chronic inflammation and nuclear factor-kappa B (NFkappaB) have been implicated in prostate cancer development; thus, dietary factors that inhibit NFkappaB may serve as effective chemo-preventative agents. Prostate cancer risk is significantly lower in Asian countries compared to the United States, which has prompted interest in the potential chemopreventative action of Asian dietary components such as soy and green tea. This study examined the effects of dietary soy and tea on NFkappaB activation and inflammation in vivo using a hormone-induced rat model for prostate cancer. Male Noble rats implanted with estradiol and testosterone were divided into 4 dietary groups: control, soy, tea, or soy+tea. NFkappaB activation and inflammatory cytokines were measured post implantation. The combination of soy and tea suppressed NFkappaB p50 binding activity and protein levels via induction of IkappaBalpha. Soy and tea also decreased prostate inflammatory infiltration, increased Bax/BcL2 ratio and decreased protein expression of tumor necrosis factor-alpha, interleukin (IL)-6 and IL-1beta compared to control. Soy and tea attenuated prostate malignancy by decreasing prostate hyperplasia. These effects were not apparent in groups treated with soy or tea alone. The ongoing in vivo studies thus far suggest that combination of foods, such as soy and tea, may inhibit hormone-induced proinflammatory NFkappaB signals that contribute to prostate cancer development.